Guzey misquotes Hemmeter et al re established antidepressant therapy

In-house rules Nov 01, 2024 · By Dennis Hackethal · Forked from Guzey properly quotes Hemmeter et al re rapid effect of sleep deprivation

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Misquote: 3 issues found

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… SD is the only established antidepressant therapy that acts within hours, and therefore, can be applied in patients with treatment-resistant depression with a chance of approximately 50% of seeing an immediate, although temporary, relief from depressive symptoms without major side effects. … The experience of realizing that depression can be lifted and sleep can improve is very important for the further therapy motivation of treatment-resistant depressed patients. … [Sleep deprivation] can be combined with antidepressant medication, predominantly serotonergic agents, with bright light therapy and with a phase advance of sleep cycles. All these strategies have been able to provide a chance to stabilize the SD response, at least in a subgroup of patients.

Original text

Nevertheless, SD is the only established antidepressant therapy that acts within hours, and therefore, can be applied in patients with treatment-resistant depression with a chance of approximately 50% of seeing an immediate, although temporary, relief from depressive symptoms without major side effects. In addition, even in patients who do not respond to SD, an elevation of mood insomnia, which is frequently accompanied by depression, may be substantially improved at least in the recovery night. The experience of realizing that depression can be lifted and sleep can improve is very important for the further therapy motivation of treatment-resistant depressed patients. In recent years, we have learned much more about the clinical effects of SD. TSD and PSD are efficient. Both can be combined with antidepressant medication, predominantly serotonergic agents, with bright light therapy and with a phase advance of sleep cycles. All these strategies have been able to provide a chance to stabilize the SD response, at least in a subgroup of patients.

Quote text

SD is the only established antidepressant therapy that acts within hours, and therefore, can be applied in patients with treatment-resistant depression with a chance of approximately 50% of seeing an immediate, although temporary, relief from depressive symptoms without major side effects. … The experience of realizing that depression can be lifted and sleep can improve is very important for the further therapy motivation of treatment resistant depressed patients. … [Sleep deprivation] can be combined with antidepressant medication, predominantly serotonergic agents, with bright light therapy and with a phase advance of sleep cycles. All these strategies have been able to provide a chance to stabilize the SD response, at least in a subgroup of patients.

Ellipsis used (if any): ‘ … ’

Diff

Nevertheless,‧SD‧is‧the‧only‧established‧antidepressant‧therapy‧that‧acts‧within‧hours,‧and‧therefore,‧can‧be‧applied‧in‧patients‧with‧treatment-resistant‧depression‧with‧a‧chance‧of‧approximately‧50%‧of‧seeing‧an‧immediate,‧although‧temporary,‧relief‧from‧depressive‧symptoms‧without‧major‧side‧effects.‧In‧addition,‧even‧in‧patients‧who‧do‧not‧respond‧to‧SD,‧an‧elevation‧of‧mood‧insomnia,‧which‧is‧frequently‧accompanied‧by‧depression,‧may‧be‧substantially‧improved‧at‧least‧in‧the‧recovery‧night.‧‧…‧The‧experience‧of‧realizing‧that‧depression‧can‧be‧lifted‧and‧sleep‧can‧improve‧is‧very‧important‧for‧the‧further‧therapy‧motivation‧of‧treatment-‧resistant‧depressed‧patients.‧In‧recent‧years,‧we‧have‧learned‧much‧more‧about‧the‧clinical‧effects‧of‧SD.‧TSD‧and‧PSD‧are‧efficient.‧Both‧…‧[Sleep‧deprivation]‧can‧be‧combined‧with‧antidepressant‧medication,‧predominantly‧serotonergic‧agents,‧with‧bright‧light‧therapy‧and‧with‧a‧phase‧advance‧of‧sleep‧cycles.‧All‧these‧strategies‧have‧been‧able‧to‧provide‧a‧chance‧to‧stabilize‧the‧SD‧response,‧at‧least‧in‧a‧subgroup‧of‧patients.

added in the quote ~~removed~~ from the original wavy not marked as a change ‧ space

Part-by-part explanation

#	Part	Valid?	Explanation
1	~~Nevertheless,‧~~	× no	Deletions must be indicated, eg by ‘ … ’ or [replacement].
2	SD‧is‧the‧only‧established‧antidepressant‧therapy‧that‧acts‧within‧hours,‧and‧therefore,‧can‧be‧applied‧in‧patients‧with‧treatment-resistant‧depression‧with‧a‧chance‧of‧approximately‧50%‧of‧seeing‧an‧immediate,‧although‧temporary,‧relief‧from‧depressive‧symptoms‧without‧major‧side‧effects.
3	‧In‧addition,‧even‧in‧patients‧who‧do‧not‧respond‧to‧SD,‧an‧elevation‧of‧mood‧insomnia,‧which‧is‧frequently‧accompanied‧by‧depression,‧may‧be‧substantially‧improved‧at‧least‧in‧the‧recovery‧night.‧	✓ yes	Deletion is followed by a valid insertion.
4	‧…‧	✓ yes	Insertion is an ellipsis.
5	The‧experience‧of‧realizing‧that‧depression‧can‧be‧lifted‧and‧sleep‧can‧improve‧is‧very‧important‧for‧the‧further‧therapy‧motivation‧of‧treatment
6	-	× no	Deletions must be indicated, eg by ‘ … ’ or [replacement].
7	‧	× no	A single added space must either follow or precede a valid insertion.
8	resistant‧depressed‧patients.
9	~~‧In‧recent‧years,‧we‧have‧learned‧much‧more‧about‧the‧clinical‧effects‧of‧SD.‧TSD‧and‧PSD‧are‧efficient.‧Both~~	✓ yes	Deletion is followed by a valid insertion.
10	‧…‧	✓ yes	Insertion is an ellipsis.
11	[Sleep‧deprivation]	✓ yes	Insertion is properly bracketed.
12	‧can‧be‧combined‧with‧antidepressant‧medication,‧predominantly‧serotonergic‧agents,‧with‧bright‧light‧therapy‧and‧with‧a‧phase‧advance‧of‧sleep‧cycles.‧All‧these‧strategies‧have‧been‧able‧to‧provide‧a‧chance‧to‧stabilize‧the‧SD‧response,‧at‧least‧in‧a‧subgroup‧of‧patients.

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