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Brilliant and exhilarating … Deutsch is so smart, and so strange, and so creative, and so inexhaustibly curious, and so vividly intellectually alive, that it is a distinct privilege to spend time in his head.

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A government is the means of placing the retaliatory use of physical force under objective control--i.e., under objectively defined laws.

TO THE MIND THAT doubts that decisive role of genius, courage, and chance in the past, the future usually seems impossible; the Western world appears doomed to decay and coercion as its growing populations press against a closing frontier, and science and technology meet the law of diminishing returns. sociology of despair is emerging, based on spurious science, incomprehension of the hardships of all human history, and blindness to the perennial sources of human triumph. While physicists begin to concede freedom for microscopic particles, social scientists still begrudge it to human beings. Atomic structure is allowed room for the random and incalculable; but social structure is supposedly under siege by mechanistic forces of en tropy and exhaustion, playing out their logic in a "closing circle" of ecological decline. These attitudes lead to systematic distortions of vision and policy. The mindset that prompts man to see the future blighted by coercion and scarcity also inclines him to believe that the present can be made as free of risk and uncertainty as the past, receding unchangeably in the lenses of hindsight.

the history of all hitherto existing society is the history of class struggles,

Scribner An Imprint of Simon & Schuster, Inc. 1230 Avenue of the Americas New York, NY 10020 www.SimonandSchuster.com Copyright © 2017 by Matthew Walker […] First Scribner hardcover edition October 2017 […] ISBN 978-1-5011-4431-8 ISBN 978-1-5011-4433-2 (ebook)

III. Cirelli, C., and Tononi, G. (2008). “Is sleep essential?” PLoS Biology. 6, e216.

Yet sleep has persisted. Heroically so. Indeed, every animal species carefully studied to date sleeps.^III This suggests that sleep evolved with—or very soon after—life itself on our planet.

The reason sleep deprivation is not a commonly used treatment, however, is that as soon as these individuals do sleep, the antidepressant benefit typically goes away. As a result, sleep deprivation alone is not a realistic or comprehensive therapy option.

Approximately 45 percent of these patients will feel better after a night without sleep.

Based on a rich, new scientific understanding of sleep, we no longer have to ask what sleep is good for. Instead, we are now forced to wonder whether there are any biological functions that do not benefit by a good night’s sleep.

Routinely sleeping less than six hours a night weakens your immune system, substantially increasing your risk of certain forms of cancer.

There’s been a pernicious erosion of sleep time throughout the past 50 years [i.e. between 1969 and 2019]

Sleepless in America, National Geographic, http://channel.nationalgeographic.com/sleepless-in-america/episode/sleepless-in-america.

[T]he prevailing belief [is] that FFI patients ultimately die of neural degeneration

[T]here is a very rare genetic disorder that starts with a progressive insomnia, emerging in midlife [fatal familial insomnia (FFI)]. Several months into the disease course, the patient stops sleeping altogether. By this stage, they have started to lose many basic brain and body functions. No drugs that we currently have will help the patient sleep. After twelve to eighteen months of no sleep, the patient will die. Though exceedingly rare, this disorder asserts that a lack of sleep can kill a human being.

Kushida, C. Encyclopedia of Sleep, Volume 1 (Elsever, [sic] 2013)

[E]very species studied to date sleeps

[C]onsidering its safety, this technique [sleep deprivation] can now be considered among the first-line antidepressant treatment strategies for patients affected by mood disorders. …

SD is the only established antidepressant therapy that acts within hours, and therefore, can be applied in patients with treatment-resistant depression with a chance of approximately 50% of seeing an immediate, although temporary, relief from depressive symptoms without major side effects. … The experience of realizing that depression can be lifted and sleep can improve is very important for the further therapy motivation of treatment resistant depressed patients. … [Sleep deprivation] can be combined with antidepressant medication, predominantly serotonergic agents, with bright light therapy and with a phase advance of sleep cycles. All these strategies have been able to provide a chance to stabilize the SD response, at least in a subgroup of patients.

The rapid effect of SD on depressive mood within hours is a fascinating experience for the patient, who may have been depressed for weeks or months …

The observation that after the recovery night a great majority of SD responders relapse into depression suggests that sleep per se may have a depressiogenic property.

Approximately 30 to 40 percent of these patients will feel better after a night without sleep. … [T]he 60 to 70 percent of patients who do not respond to the sleep deprivation will actually feel worse, deepening their depression. As a result, sleep deprivation is not a realistic or comprehensive therapy option.

Approximately 30 to 40 percent of these patients will feel better after a night without sleep … the 60 to 70 percent of patients who do not respond to the sleep deprivation will actually feel worse, deepening their depression. As a result, sleep deprivation is not a realistic or comprehensive therapy option.

[W]e are now forced to wonder whether there are any biological functions that do not benefit by a good night’s sleep. So far, the results of thousands of studies insist that no, there aren’t.